Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The idea of workplace democracy is not on the political agenda. And yet, democratic firms exist in various forms in today's economy. The idea and the practice is not only economically and philosophically challenging. The worries to which it responds are not bew either. This is well illustrated by John Stuart Mill's conjecture of the end of the wage-earner system, dating back to more than one century ago.

Five experiments investigated how people use categories to make inductions about objects whose categorisation is uncertain. Normatively, they should consider all the categories the object might be in and use a weighted combination of information from all the categories: bet-hedging. The experiments presented people with simple, artificial categories and asked them to make an induction about a new object that was most likely in one category but possibly in another. The results showed that the majority of people focused on the (...) most likely category in making inductions, although there was a group of consistently normative responders who used information from both categories (about 25% of our college population). Across experiments the overall pattern of results suggests that performance in the task is improved not by understanding the underlying principles of bet-hedging but by increasing the likelihood that multiple categories are in working memory at the time of the induction. We discuss implications for improving everyday inductions. (shrink)

Leave No Trace (LNT) has become the official education and outreach policy for managing recreational use in parks and wilderness areas throughout the United States. It is based on seven core principles that seek to minimize impacts from backcountry recreational activities such as hiking, climbing, and camping. In this paper, we review the history and current practice of Leave No Trace in the United States, including its complex role in the global political economy of outdoor recreation. We conclude by suggesting (...) a new framework for building on the successes of Leave No Trace, while moving beyond its self-imposed limitations, and recapturing wilderness recreation as a more collaborative, participatory, productive, democratic, and radical form of political action. (shrink)

This work is essentially a history of the scholastic conception of dialectica from Garlandus Compotista to William Ockham, with an eye to rendering intelligible the puzzling nature of late medieval treatises on logical obligations. Such treatises seem to countenance violations of fundamental and indisputable logical rules, for example, that a disjunction is false if both of its disjuncts are false. In large part to explain this apparent surd development in medieval logic, Eleonore Stump has collected into a single volume twelve (...) separately published essays. Together they form an interesting and convincing argument. (shrink)

Death is the destiny we all share, and this will not change. Yet the way we die, which had remained the same for many generations, has changed drastically in a relatively short time for those in developed countries with access to healthcare. For generations, if people were lucky enough to reach old age, not having died in infancy or childhood, in childbirth, in war, or by accident, they would take to bed, surrounded by loved ones who cared for them, and (...) fade into death. Most likely, they would have seen their parents and grandparents die the same way, and so this manner of dying would be familiar: it was part of the natural cycle of life. Now less than 25 per cent of Americans die at home, having reached much older ages than people would have dreamed of in past generations, often after surviving many illnesses and even diseases that would have been terminal for their grandparents. We are fortunate to live (and die) today, supported by myriad scientific, medical, and technological advancements, however we also face new problems as a result of the new way in which we die. We can no longer anticipate a peaceful waning at home with family. We know our lives will likely end in hospitals likely after we have endured grueling treatments to prolong life. We have to decide what decisions we want our loved ones, or care-givers, to make when we cannot choose for ourselves. We have to think about whether in any circumstances we would seek physician-assisted death. We know we face other questions as well, but we may not even know where to start. In the face of these decisions, we can feel daunted and afraid. The best remedy is information and planning. In this book, Gregory Eastwood - a physician who has cared for dying patients, served as an ethics consultant, and taught end of life issues to medical and other health profession students - draws from his substantial experience with patients and families to provide the information that will help us think clearly about the choices and issues we will face at the end of our own lives, and when faced with the deaths of our loved ones. With sensitivity and profound insight, Eastwood guides us through all the important questions about death and dying in straightforward, clear language, enhanced by real-life stories. Throughout, he shows us how we can take ownership of the way we want to die, when we must die, and feel more in control as death approaches. (shrink)

We prove that any positive elementary (least fixed point) induction expressing the negation of transitive closure on finite nondirected graphs requires at least two recursion variables.

Jacques Derrida's Politics of Friendship is adopted as a theoretical guide to the mutation of metaphysical categories under way in the shift from literacy to electracy. The politics is embodied in the design of a digital “memory palace,” created by the Florida Research Ensemble, whose setting is the city of Miami, Florida. Listening with an ear attuned by Derrida, through Freud and Heidegger, one hears in “Miami” a creole phrase “my friend” resonating with the aphorism by Aristotle—“O my friend, there (...) is no friend”—whose “event” Derrida traces to the “other” beginning. His alternative politics of hospitality is articulated with the history of prudence and the possibility of an image category supporting digital deliberative reason in an Internet public sphere. (shrink)

This chapter focuses on one of the common fallacies in Western philosophy, appeal to ridicule. An appeal to ridicule is closely related to an ad hominem argument because both attack the person. There is a similarity between an appeal to ridicule and an appeal to emotion in that both attempt to bypass rational assessment of a point of view and elicit an emotional reaction from the audience. An appeal to ridicule may be an attempt to elicit humor at another's expense, (...) or it may be an attempt to elicit enmity, playing on the fears and prejudices of the group. The difference between a reductio ad absurdum and an appeal to ridicule is that the former uses good evidence while the latter does not. Perhaps the best way to avoid this fallacy is to cultivate an attitude of respect for other points of view. (shrink)

The charges of fideism and relativism have long been leveled against Wittgensteinian philosophy of religion. However, the philosopher most influenced by Wittgenstein's understanding of religion, D. Z. Phillips, is guilty of neither fideism nor conceptual scheming. The contribution of Wittgenstein to an understanding of religious belief is much more nuanced than critics generally appreciate. Likewise, the relationship of Wittgenstein's philosophy to that of Davidson and to pragmatism, especially in its Rortyan manifestations, is shown to be friendlier than is often recognized.

Extending the dialogue on corporate social performance (CSP) as descriptive stakeholder management (Clarkson, Acad Manage Rev 20: 92, 1995), we examine differences in CSP activity between family and nonfamily firms. We argue that CSP activity can be explained by the firm's identity orientation toward stakeholders (Brickson, Admin Sci Quart 50: 576, 2005; Acad Manage Rev 32: 864, 2007). Specifically, individualistic, relational, or collectivistic identity orientations can describe a firm's level of CSP activity toward certain stakeholders. Family firms, we suggest, adopt (...) a more relational orientation toward their stakeholders than nonfamily firms, and thus engage in higher levels of CSP.Further, we invoke collectivistic identity orientation to argue that the higher the level of family or founder involvement within a family firm, the greater the level of CSP toward specific stakeholders. Using social performance rating data from 1991 to 2005, we find that family and nonfamily firms demonstrate notable differences in terms of social initiatives and social concerns. We also find that the level of family and founder involvement is related to the type and frequency of a family firm's social initiatives and social concerns. (shrink)

Six experiments investigated variables predicted to influence subjects’ tendency to classify items by a single property instead of overall similarity, following the paradigm of Norenzayan et al., who found that European Americans tended to give more “logical” rule-based responses. However, in five experiments with Mechanical Turk subjects and undergraduates at an American university, we found a consistent preference for similarity-based responding. A sixth experiment with Korean undergraduates revealed an effect of instructions, also reported by Norenzayan et al., in which classification (...) instructions led to majority rule-based responding but similarity instructions led to overall similarity grouping. Our American subjects showed no such difference and used similarity more overall. We conclude that Americans do not have a preference for rule responding in classification and discuss the differences between tasks that reliably show strong rule or unidimensional preferences in contrast to this classification paradigm. (shrink)

We present game-theoretic characterizations of the complexity/expressibility measures “dimension” and “the number of variables” as Least Fixed Point queries. As an example, we use these characterizations to compute the dimension and number of variables of Connectivity and Connectivity.

This paper explores the scriptural and theological reasons given by Jehovah's Witnesses (JWs) to refuse blood transfusions. Julian Savulescu and Richard W Momeyer argue that informed consent should be based on rational beliefs and that the refusal of blood transfusions by JWs is irrational, but after examining the reasons given by JWs, I challenge the claim that JW beliefs are irrational. I also question whether we should give up the traditional notion of informed consent.

When a structure or class of structures admits an unbounded induction, we can do arithmetic on the stages of that induction: if only bounded inductions are admitted, then clearly each inductively definable relation can be defined using a finite explicit expression. Is the converse true? We examine evidence that the converse is true, in positive elementary induction . We present a stronger conjecture involving the language L consisting of all L∞ω formulas with a finite number of variables, and examine a (...) combinatorial property equivalent to “all L-definable relations are elementary”. (shrink)

Volume 1 -- Unit 1: Tragedy as an independent art of musical drama. Chapter 1: Plato's well-educated men, the dancers: Harmonia kai rhuthmos as "music and dance" -- Chapter 2: Tragedy as a necessarily performed "musical" art in the Poetics -- Chapter 3: The irreducibility of tragedy to literature -- Chapter 4: Harmonia kai rhuthmos as "music and dance" in Politics VIII.

In recent years, many in medical education have examined the question of how best to reinvigorate the doctor-patient relationship, given the increasing technological distance that has emerged between them in modern medicine. In this paper it is argued that “humanism” and caring in medicine reflect the quality of transitional relatedness in the illness condition, a significant separation-attachment phase of life. By improving our understanding of the origin of caring, educational strategies for physicians in training may improve as might our abilities (...) to provide care. (shrink)

The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module found in multiple copies in a number of functionally different proteins that facilitates specific interactions with a partner protein(s). Three-dimensional structural data have shown that a TPR motif contains two antiparallel α-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that might accommodate the complementary region of a target protein. Most TPR-containing proteins are associated with multiprotein complexes, and there is extensive evidence (...) indicating that TPR motifs are important to the functioning of chaperone, cell-cycle, transcription, and protein transport complexes. The TPR motif may represent an ancient protein-protein interaction module that has been recruited by different proteins and adapted for specific functions. BioEssays 1999;21:932–939. © 1999 John Wiley & Sons, Inc. (shrink)

The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module found in multiple copies in a number of functionally different proteins that facilitates specific interactions with a partner protein(s). Three-dimensional structural data have shown that a TPR motif contains two antiparallel α-helices such that tandem arrays of TPR motifs generate a right-handed helical structure with an amphipathic channel that might accommodate the complementary region of a target protein. Most TPR-containing proteins are associated with multiprotein complexes, and there is extensive evidence (...) indicating that TPR motifs are important to the functioning of chaperone, cell-cycle, transcription, and protein transport complexes. The TPR motif may represent an ancient protein-protein interaction module that has been recruited by different proteins and adapted for specific functions. BioEssays 1999;21:932–939. © 1999 John Wiley & Sons, Inc. (shrink)

We prove the hereditary undecidability of the L t theories of: (1) torsion-free Hausdorff topological abelian groups; (2) locally pure Hausdorff topological abelian groups.

Francesco Casetti _Theories of Cinema: 1945-1995_ Translated by Francesca Chiostri and Elizabeth Gard Bartolini-Salimbeni, with Thomas Kelso Austin: University of Texas Press, 1999 ISBN 0-292-71207-3 368 pp.

In a recent Journal of Medical Ethics article, ‘Should Religious Beliefs Be Allowed to Stonewall a Secular Approach to Withdrawing and Withholding Treatment in Children?’, Joe Brierley, Jim Linthicum and Andy Petros argue for rapid intervention in cases of futile life-sustaining treatment. In their experience, when discussions of futility are initiated with parents, parents often appeal to religion to ‘stonewall’ attempts to disconnect their children from life support. However, I will argue that the intervention that the authors propose is culturally (...) insensitive. (shrink)

Robert Larmer critiques my view that the correct interpretation of David Hume’s argument against miracles in “Of Miracles” is that no testimony of a miracle can serve as the foundation of a religion. Larmer thinks that there is no unified argument in the section but says that Hume’s essential argument is that there can never be a justification for believing that a miracle has occurred on the basis of testimony. I raise a number of problems with Larmer’s interpretation, not the (...) least of which is the fact that Hume explicitly contradicts such a reading. (shrink)